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Clinical Plucked Hair Analysis

Hair Analysis: A Surrogate Tissue for Clinical Studies

Epistem provides a highly sensitive and powerful platform for the analysis of hair collected during clinical studies either for market approval or post-marketing for patient stratification. Epistem has conducted GCLP accredited clinical studies in support of drug development pipelines for a number of major pharmaceutical customers. Hair is an ideal surrogate tissue as it is easy to sample, has good patient compliance and few ethical issues.

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Plucked Hair Sampling: A Simple and Ethical Method for Hair Collection

Plucked Hair Sampling

Hair sampling is a simple and non-invasive method that involves the collection of hair from the scalp. Epistem provides sampling kits that include a collection guide to ensure that the samples are collected correctly and with optimal quality. These kits are designed to be easy to use, and instructions are provided to ensure that the hair is collected in a manner that is consistent with clinical trial requirements.

In addition to providing sampling kits, Epistem offers further training in hair sampling to ensure that hair is collected in the most efficient and effective way possible. This training is designed to ensure that the samples are of the highest quality and meet the requirements of the study protocol.

After the hair is collected, it is rapidly fixed at the collection site to preserve the integrity of the hair tissue. This fixation ensures that the hair is stable during transport and analysis. The fixed hair samples are then shipped to Epistem for analysis using their advanced hair analysis platform.

Plucked Hair Analysis

Protein Expression

Epistem has developed techniques for reliable and reproducible protein quantification in single plucked human hairs by immunohistochemistry and ELISA. Protein expression and site-specific phosphorylation can be detected and quantified using either whole mount or longitudinal sectioning techniques. Labelling protocols and quantification methods can be developed for each antigen.

Gene Expression

Profiling of hairs is possible using Epistem’s proprietary gene expression technologies. Small amounts of RNA are extracted from the hair bulb and gene expression levels are determined by either microarray or qRT-PCR analysis.

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