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Plucked Hair Analysis

Innovative Hair Biomarker Platform for Drug Development

Discover the power of hair biomarker platform for drug development. Epistem's plucked hair assay provides highly sensitive and valuable preclinical proof of concept data on protein and gene expression. With in-house expertise and proprietary techniques, it offers a powerful tool for drug discovery and development.

An Overview

Hair is an ideal surrogate tissue for monitoring drug response, making the process easy, convenient and ethical for patients. Collect multiple samples with minimal discomfort and maximise your clinical study outcomes.

Preclinical Plucked Hair Assay

Epistem’s extensive knowledge of epithelial biology has been translated into a unique hair biomarker platform. Epistem’s plucked hair assay can be used to determine the effects of novel therapeutic agent exposure on protein and gene expression in hair, providing valuable preclinical proof of concept data.

Clinical Plucked Hair Assay

Epistem provides a highly sensitive and powerful platform for the analysis of hair collected during clinical studies, either for market approval or post-marketing for patient stratification.

Biomarker identification, validation and screening

Profiling of hairs is possible using Epistem’s proprietary gene expression technologies.

Ex vivo hair culture

Hair plucked from healthy normal volunteers is incubated in culture, allowing us to establish drug-related changes in gene expression which can guide selection of clinical biomarkers.

Hair IHC

Epistem has developed techniques for reliable and reproducible immunohistochemistry labelling of single plucked human hairs for a number of antigens.

Hair expression profiling can assist drug development programs in monitoring pharmacodynamic response to treatment, duration of drug effect, dose response, confirmation of mechanism of action, patient stratification and hair growth. Hair can be profiled in both rodents and humans during preclinical and clinical studies. The scalp is the preferred source of plucked hair in humans, as most hairs in this region are in the anagen (active growth) phase of the hair cycle.

Epistem’s extensive database containing gene expression profiling information from mouse, rat and human samples can confirm if genes of interest are expressed in hair. They provide a highly sensitive and powerful platform for the analysis of hair collected during clinical studies, either for market approval or post-marketing for patient stratification. Biomarker identification, validation, and screening are possible using their proprietary gene expression technologies.

Epistem also offers ex vivo hair culture, which allows them to establish drug-related changes in gene expression and guide the selection of clinical biomarkers. They have also developed techniques for reliable and reproducible immunohistochemistry labelling of single plucked human hairs for a number of antigens.

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Contact Information

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