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In Vivo Wound Healing

A powerful tool for evaluating the efficacy and safety of novel therapeutic agents in wound healing research.

Epistem provides advanced in vivo wound healing models that enable the evaluation of novel therapeutic agents on the rate of healing and scarring. Our acute excisional and incisional wounding models include a unique human skin xenograft model that closely emulates the human wound healing process, providing invaluable insights into drug efficacy and safety. Additionally, we offer an inflamed wound healing model where incisional wounds are treated with Lipopolysaccharide (LPS) from Klebsiella pneumoniae, a potent inflammatory agent that impairs wound healing. These models are designed to be versatile and customisable to meet the specific research needs of our clients.

What's Available

Discover how Epistem's in vivo wound healing assays can accelerate your wound healing research by offering a selection of acute and chronic wounding models.

Acute In Vivo Models

Epistem offers acute excisional and incisional wounding models including a human skin xenograft model which closely mimics the human wound healing process.

An inflamed wound healing model is also available, where incisional wounds are treated with Lipopolysaccharide (LPS) from Klebsiella pneumoniae which impairs healing.

Chronic In Vivo Models

Epistem provides a range of in vivo chronic wound healing models, including models for delayed wound healing in cutaneous diabetic conditions (Type 1 and Type 2) and an ovariectomy (OVX) model that accurately represents the most clinically relevant indications of age-associated wound healing caused by oestrogen deficiency in postmenopausal adults.

Epistem’s wound healing models can be customised to investigate the impact of gender, hormones, and age on wound healing. These models can assess various aspects of wound healing, such as wound closure, re-epithelialisation, angiogenesis, granulation tissue maturity, collagen deposition, and inflammatory response.


  • Wound closure and degree of scarring
  • Histology and immunohistochemistry
  • Image analysis (Aperio® ScanScope®)
  • Cytokine profilng
  • Gene expression

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Contact Information

For more information regarding our services, please do not hesitate to contact us.