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Human Skin Xenografts

Chimeric models of engrafted human skin can provide a valuable tool for advancing the development of new treatments and therapies.

Epistem's human skin xenografts can be used in various ways, such as assessing the efficacy and safety of novel therapeutic agents, determining the mechanism of action, providing evidence for claims and patent support, and offering proof of concept biomarker data prior to clinical trials.

Implementation & Assessment

Engraftment Procedure for Epistem's Chimeric Model of Human Skin

Human skin is engrafted onto an immunocompromised host. Following this procedure, novel therapeutic agents can be applied either topically or systemically for an average of six weeks. During this time, samples can be taken at various time points for analysis.

The model’s ability to assess the efficacy and safety of novel therapeutic agents is particularly valuable, as it allows researchers to monitor the results of these agents over a defined period of time. Additionally, the model can help determine the underlying mechanisms of action of these agents, shedding light on how they work and potentially informing future research.

Another benefit of the model is its ability to provide evidence for claims and patent support. By generating proof of concept biomarker data, the model can help support the validity of patent claims and demonstrate the potential value of new treatments and therapies.

Overall, Epistem’s chimeric model of engrafted human skin offers a versatile and valuable tool for advancing research in the field of medicine.

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