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Organoids

Unlocking the Power of Organoids: Revolutionise Your Research with Cutting-Edge Models

Using the renowned Hans Clevers method, our expert team has developed organoid models for both the intestine and liver. These models allow for the assessment of potential off-target or off-tissue toxicities of new therapeutic agents on normal tissue. Compared to traditional 2D cell cultures, organoids offer a more accurate representation of in vivo physiology by closely mimicking the structure and function of the target tissue. Furthermore, organoids can be generated from patient-derived tissue, enabling personalised medicine approaches that may result in more effective treatments with fewer side effects.

Our Available Organoids

As part of our 3D in vitro assay offering, we have developed liver and intestinal organoid models.

Intestinal Organoids

Our intestinal organoid model is based on progenitor cells that regenerate tissues and closely resemble the in vivo structure, including all differentiated cell types. This model allows us to assess the effects of test agents on organoid viability and the production of crypt-like branching structures. We evaluate a range of candidates, including Wnt regulators, cytokines/growth factors, steroids, lectins, and kinase inhibitors. Furthermore, the intestinal organoid model is well-suited for high throughput screening of drug candidates, enabling rapid identification of promising therapies and more efficient drug development pipelines.

Additionally, intestinal organoids can be modified to mimic specific diseases, providing a powerful tool for studying disease mechanisms and developing new treatments.

Intestinal organoids offer several readouts, including:

  • Viability and proliferation
  • Immunohistochemistry
  • In situ hybridisation (RNAscope)
  • Cytokine profiling
  • Flow cytometry
  • Gene expression (NGS, array, PCR)

Liver Organoids (In Development)

Our liver organoid model is derived from mouse hepatic duct fragments and enables the study of hepatic pluripotent and progenitor cells’ growth and the tissue response to novel therapeutic agents. We can assess the effects of test agents on organoid viability and uptake of rhodamine 123 to evaluate biliary function. Candidates evaluated include transporter-targeted drugs, steroids, farnesoid X receptor agonists and antagonists.

Liver organoids are a versatile tool for studying a wide range of biological processes and disease mechanisms as they can be derived from both healthy and diseased tissue. They can be used to test the metabolism and toxicity of potential drug candidates, allowing for more efficient and accurate drug development pipelines.

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