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Therapy Side Effects

Revolutionising Medical Research with Epistem's Alopecia and Mucositis Models

Many oncology therapies lack tumour specificity and cause collateral damage to normal healthy tissues. Common side effects of cancer therapy include alopecia, oral and gastrointestinal mucositis, and particularly following radiotherapy, bone marrow toxicity. These side effects can become so severe that they are life-threatening.

Alopecia Model & Mucositis Models

Epistem provides a range of preclinical models that can be used to determine toxicity effects of novel chemotherapy agents and assess the efficacy of novel therapeutic agents to treat and reduce these side effects.

Alopecia Model

A defined area receives a high dose of radiation to induce alopecia. Novel therapeutic agents can be administered topically or systemically. Epistem can determine the effect of a novel therapeutic agent on the different stages of the hair cycle and propensity to inhibit hair growth or cause hair loss.

Services offered to assess chemotherapy-induced alopecia include:

  • Plucked Hair Analysis
  • Histology & Image Analysis
  • Immunohistochemistry
  • Gene Expression Analysis

Mucositis Models

Our mucositis models are designed to replicate the painful and debilitating inflammation of the mucous membranes that can occur as a side effect of cancer treatments such as chemotherapy and radiation therapy. With this model, researchers can investigate potential treatments for mucositis and improve the quality of life for cancer patients undergoing these treatments. Epistem provides in vivo oral and gastrointestinal models which can be used to assess novel anti-mucositis therapies and to evaluate the clinical risk of mucositis induction by novel therapeutic agents.

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