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Target Validation

Target validation plays a pivotal part during the development of novel therapeutics.

To demonstrate a molecular target is involved in the incidence of disease, and that any modulation would result in a remedial affect, in vitro target validation assessments can be used. Investigation into the toxicity of novel therapeutics on non-target cells and tissues can also be established using in vitro target validation.

What's Available

Epistem offers a range of service options for the assessment of preclinical novel therapeutic agents including:

Target Expression Pathway Analysis via

  • Immunohistochemistry (IHC)
  • Image Analysis
  • Gene Expression Profiling (including with low-DNA samples)
  • Plucked Hair Analysis

 

Access to Human Cancer Stem Cell Lines

  • 2D Cell Cultures vs 3D Neoplastic Spheroids

 

Cytotoxicity Assays

  • IC50 and EC50 Doses
  • Viable Cell Number, Proliferation and Apoptosis
  • IHC with Antigen Stability during Storage & Culture
  • Fluorescence-Activated Cell Sorting (FACS) Analysis of Target Expression

 

Angiogenesis Assays

  • IHC and Image Analysis on Vessel Length & Branching

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