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Orthotopic Models

Epistem provides a service that offers orthotopic models of Acute Myeloid Leukaemia (AML), Acute Lymphoblastic Leukaemia (ALL), Lung, Ovarian and Prostate cancer.

Cell lines are lentivirally transduced with luciferase and GFP, enabling disease progression and response to novel therapeutic agents to be monitored longitudinally using Epistem's state-of-the-art imaging facility. All of our models are fully complemented by our range of in vitro and ex vivo assays, as well as our comprehensive FACS, histology and biomarker analytical services.

Leukaemic vs Solid Tumour

Epistem offers offers a range of in vivo models to help support drug development

Leukaemic Orthotopic Models

These models are designed to mimic the growth patterns and microenvironment of human leukaemia, making them valuable tools for evaluating the efficacy and toxicity of new drugs. Our team of experts can help customers design and execute preclinical studies using these models, enabling them to make informed decisions about the development of potential therapeutics for the treatment of leukaemia.

Solid Tumour Orthotopic Models

These models provide a more physiologically relevant platform to evaluate the efficacy of potential cancer treatments, as the tumour is grown within the natural microenvironment of the host tissue. This allows for a more accurate assessment of the drug’s effectiveness and safety, and can better predict clinical outcomes.

 

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