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Inflammatory Bowel Disease

Revolutionise Your IBD Research with Advanced Models

Epistem has extensive expertise and knowledge of the gastrointestinal epithelium, which we've applied to several well-established models of Inflammatory Bowel Disease (IBD). Our IBD team has years of experience and regularly runs these models for clients in biotechnology, pharmaceutical companies and academic laboratories. Let us help with your IBD research needs.

An Overview

Access the Latest Tools and Technology for More Accurate Results and Better Insights into Inflammatory Bowel Disease.

Inflammatory Bowel Disease (IBD) encompasses Crohn’s disease and Ulcerative Colitis (UC), which share similar clinical symptoms but result from different underlying pathologies. The mucosal immune system is inappropriately activated in response to antigens, leading to the inflammation associated with IBD. IBD has a multifactorial etiology, with genetic, environmental, and immunological factors believed to play a role in its development and progression. At Epistem, we recognize the significance of using reliable and precise research models to advance our understanding of IBD and develop new therapeutic approaches. Our models enable the assessment of novel drugs and therapies, offering valuable insights into disease mechanisms and potential treatment options.

Epistem’s preclinical models replicate aspects of IBD in humans and can be used to generate target validation and mechanism of action data to confirm efficacy of novel therapeutic agents.

Epistem’s models of Inflammatory Bowel Disease:
• DSS Induced Acute and Chronic Mediated Colitis
• Adoptive T-cell Transfer Mediated Colitis
• IL-10 knockout spontaneous colitis
• Bespoke Colitis Models

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