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In Vivo Mucositis Models

The gold standard models are used to assess the likelihood of a novel therapeutic agent causing mucositis and can help devise dosing strategies to minimise toxicity

Chemotherapy and radiotherapy are the most common and effective oncology therapies but adversely affect healthy tissue. Ongoing research seeks to improve the precision and effectiveness of these therapies while minimising their impact on healthy tissue. Epistem's mucositis team have been working in this area for over 20 years and have been involved with the preclinical development of many candidate therapies.

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The Development of Anti-Mucositis Therapeutics

Systemic chemotherapy can cause painful and dose-limiting ulceration of both the intestine and oral mucosa. Treatment with focal radiotherapy, commonly used for head and neck, large bowel and prostate cancer, can cause similar oral or colonic lesions.
The cells lining the crypts of the small intestine are the most rapidly proliferating in the body and are therefore particularly sensitive to interruption in cell proliferation caused by oncology therapy.
If the stem cells within the intestinal crypts are killed, ulceration can occur resulting in diarrhoea, dehydration and infection. Cell turnover in the oral cavity is slower than in the small intestine, oral ulcers are therefore slower to manifest. Oral ulcers are very painful and of great clinical concern; due to lack of patient compliance oncology therapy can be withdrawn, or treatment intensity reduced to prevent further damage.

An important consideration in the development of anti-mucositis therapeutics is that the novel therapeutic agent must not protect tumours or promote tumour growth. Epistem have the capabilities to evaluate the effect of a therapeutic agent on tumour growth using xenograft models.

 

Epistem’s Mucositis Models:
• Oral mucositis
• Gastrointestinal mucositis

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