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GI Toxicity & Mucositis

World renowned knowledge of gastrointestinal epithelial biology has been translated into a suite of preclinical models.

Based on research of Epistem's co-founders, Prof. Chris Potten and Dr. Cath Booth, who identified and characterised the location and behaviour of stem cells in the intestine, including the damaging effects of chemotherapy and radiotherapy on the various cell populations.

An overview

The epithelium provides a barrier between the body and its environment. Due to its dynamic epithelial structure and rapid cell proliferative state, the lining of the small intestine provides a unique environment in which to understand epithelial changes, cell regulation and mechanism of action of novel therapeutic agents.

GI Toxicity

Epistem have developed a powerful understanding of the fundamental control of cell turnover and differentiation in the intestine. This knowledge aids to elucidate the cause of GI toxicity and how it may be controlled by therapeutics. The application of this understanding to commercial models remains unmatched in the field.

These models can be used to support the development of novel therapeutic agents to:

  • Prevent or treat gastrointestinal or oral toxicity
  • Evaluate the risk of novel therapeutics causing toxicity
  • Devise dosing strategies to minimise off-target responses

GI Toxicity models available:

  • 2D in vitro GI models
  • In vivo GI models

Mucositis

Mucositis is a specific form of GI toxicity associated with oncology therapy. Epistem’s gold standard in vivo mucositis models can be used to assess whether a novel therapeutic agent causes mucositis. The mucositis team have been working in this area for over 20 years and were involved in the preclinical development of the only licensed prophylactic treatment for oral mucositis; Kepivance® (palifermin). This expertise in radiation biology has been recognised by the National Institute of Health (NIH) where Epistem’s models of radiation-induced intestinal toxicity have been employed to evaluate potential radiation countermeasures.

3D intestinal organoid models available:

  • Mucositis
  • Oral mucositis
  • Gastrointestinal mucositis

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