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Acute Radiation Syndrome (ARS) Models

Expertise in Radiation Biology

Epistem offers full histological evaluation and detailed dosimetry to support our models, ensuring you have the information you need to make informed decisions. Let us help you unlock new insights into radiation biology research and take your research to the next level.

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X-ray irradiation is performed with bone marrow shielding where required. Full dosimetry of the 320kV source is also performed for each study run.

Gastrointestinal – Acute Radiation Syndrome

Radiation kills the rapidly proliferating clonogenic cells in intestinal crypts. If all the clonogenic cells are killed, the crypt will die. If sufficient crypts die, ulcers will form, resulting in diarrhoea, infection, dehydration and death.

Readouts

  • Survival
  • Diarrhoea duration and severity
  • Crypt Survival
  • Apoptosis and proliferation
  • Cytokine analysis by multiplex
  • Protein expression
  • Gene expression
  • Histology

Haematopoietic – Acute Radiation Syndrome

The effects of H-ARS manifest later than GI-ARS, however, the bone marrow is highly sensitive. A lower dose of irradiation is therefore required and detrimental effects manifest over a longer time course than GI-ARS (apparent from day 10 onwards).

Readouts

  • Survival
  • Histology of the bone marrow
  • Cytokine analysis by multiplex
  • Protein expression
  • Gene expression